Optochemical Control of Therapeutic Agents through Photocatalyzed Isomerization
نویسندگان
چکیده
A Ru(bpy)3Cl2 photocatalyst is applied to the rapid trans cis isomerization of a range alkene-containing pharmacological agents, including combretastatin A-4 (CA-4), clinical candidate in oncology, and resveratrol derivatives, switching their configuration from inactive substances potent cytotoxic agents. Selective cellulo activation CA-4 analog Res-3M demonstrated, along with its cytotoxicity inhibition microtubule dynamics.
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2022
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202203390